Introduction
VKGL/VKGN ‘NGS in DNA diagnostics’ is a course aimed at Genomic Resequencing in a Medical Diagnostic Context, i.e to apply Next Generation Sequencing data as diagnostic tool in the hospital. Lectures will be accompanied with hands-on exploration.

Program Outline (preliminary)

• Day 1 consists of an introduction to NGS techniques followed by specialised lectures on sample preparation, enrichment technologies and read mapping.
• Day 2 will continue with lectures on variant calling, annotation and interpretation with a diagnostic emphasis applied to Gene Capturing Panels, Exome Screening and CNV analysis.
• The afternoon of Day 1 & Day 2 is reserved for workshops and software demonstrations. Real data will be used where possible in hands-on tutorials using both commercial and open source software.
• Day 3 focuses on impact of results in the lab and ethical and legal issues of NGS in the clinical application. Real-life applications of NGS in the clinic will be presented. A forum discussion between researchers and clinicians about mutual expectations, ethics, implications of NGS on diagnostics and data sharing concludes the day.

  Target audience
  This course is intended for bioinformaticians, researchers and molecular & clinical geneticists. The mixed programme will appeal to all those requiring a solid background in the application of NGS techniques for (routine) genetic diagnosis of a patient. The course will be mainly in English.

    

  Organisation, Accreditation and Registration
  The course is a joint effort from individuals of the NVHG/VKGL/VKGN (diagnostic) community of The Netherlands, and has been awarded:

  • 17 points by the VKGN.
  • 18 points by the CMI (College Medisch Immunologen) - part of the NVvI (Dutch Society of Immunology)
  • VKGL-members may contact the VKGL afterwards with their certificate of participation to acquire their points.  

   

  ECTS

  This course including self-study is 1,0 ECTS.

  
  
  Course material

   

  You will find the presentation slides via this link: http://biosb.nl/education/course-portfolio-2/course-genome-resequencing-in-medical-diagnostics-2016/ 

  
  Date and Location
  The course will be held at the Erasmus Medical Centre, Medical Faculty, at the 'Onderwijscentrum' (Educational Centre, rooms are mentioned ‘OWR nr. NN’).

  • The course will start in lecture room: t.b.a.
  • Three computers will be used on Tuesday and Wednesday afternoon (t.b.a.)

  See here for maps of the Erasmus MC, including the Educational centre: https://www.molmed.nl/maps/maps.asp

   

   

  Registration fees

  • €250 for PhD students (€200 for 2 days)
  • €500 for researchers at universities or non-profit research institutes (€400 for 2 days)
  • €1000 for researchers from profit organizations (industry) (€800 for 2 days)
  • The fee for all other participants is: €500 (€400 for 2 days)

  Additional remark: AIOs are not considered PhD-students and will thus also not receive the reduced PhD-fee.

   

  PAYMENT: MGC Notification

  The Erasmus/LUMC Research School MGC has made a selection of courses it deems fit for its members. This course is not one of them.

  Therefore, the Erasmus/LUMC Research School MGC will not pay for its members to participate in this course. All MGC-members will need to pay themselves (or from personal budget) after receiving an invoice (please provide personal address) or will have their research departments pay for them (in that case, please provide ‘kostenplaatsnummer’ of the research group). To see if you are an MGC-member, here you can find an overview of all MGC research groups: http://www.medgencentre.nl/