Monocytes: origins, destinations, functions and diagnostic targets

Course date: 16 November 2017 - 16 November 2017
Location: Erasmus MC, OWR-39

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In clinical and basic research, peripheral blood monocytes constitute an intriguing study population. Since several years, it has been noticed that these macrophage-/DC-precursors are heterogeneous, comprising so-called classical, intermediate and non-classical monocytes. These subsets show differential expression of CD14 and CD16 in human, and Ly-6C and CD43 in mouse, and respond differently to inflammatory triggers. Interestingly, several clinical conditions have been linked to shifts in these monocyte subsets, but functional interpretation of these findings remain difficult in view of their diverse functions.

In this mini-symposium, we aim to reach investigators from different departments at Erasmus MC, who are interested in learning and discussing the state-of-the-art in blood monocyte heterogeneity. Opinion leaders in the field of human and mouse monocyte biology, namely prof. Loems Ziegler-Heitbrock and dr. Alexander Mildner, have been invited to share their latest insights with us.


13.00 Coffee and Tea
13.25 Opening  -  Yvonne Bastiaansen  -  Pieter Leenen
13.30 Blood monocytes and their subsets in health and disease.
Loems Ziegler-Heitbrock, Helmholtz Center, Munich
14.10 Murine monocyte differentiation under physiological and   pathological conditions
Alexander Mildner, Max-Delbrück-Centrum for Molecular Medicine, Berlin
14.50 Monocytes and macrophages and their role in solid organ transplantation.
         Ajda T. Rowshani and Thierry van den Bosch, Dept. of Internal Medicine, Erasmus MC
15.15 Break
15.35 Kinetics and heterogeneity of the monocyte-macrophage system in case of tissue disruption
Wouter van de Bossche, Dept. of Immunology, Erasmus MC
16.15 Monocytes and macrophages in orthopedics
Niamh Fahy, Dept. of Orthopedics, Erasmus MC
16.35 CD16 expression by human monocytes: Beware!
Pieter Leenen, Dept. of Immunology, Erasmus MC
16.55 Drinks

Organizers: Pieter Leenen & Yvonne Bastiaansen, Erasmus MC Rotterdam  

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