More information about PhD position Rabies project

Project description

Rabies virus (RABV), transmitted by a bite or scratch of an infected animal, causes RABV- encephalitis. Rabies mortality approaches 100% in victims showing clinical signs and not vaccinated prior to exposure or not treated by immediate post-exposure prophylaxis (PEP). PEP is effective but often too costly and not available to victims in most endemic areas. Alternative treatments are therefore urgently needed to reduce the annual burden of at least 60.000 reported deaths worldwide. Up to present the exact understanding of RABV pathogenesis has not been unravelled. In the search of novel avenues for therapeutic intervention it is crucial to increase understanding of the immune response and pathogenesis of RABV infection. Your work will focus on identifying mechanism used by the virus to evade or suppress the host immune system. In later phases of the project, testing of novel post-exposure treatments will be included. You will work with both in vivo and in vitro models of RABV infection. Techniques will include flow cytometry, cytometric bead assays, virus neutralization assays, immunohistochemistry, confocal laser microscopy and primary cell cultures.
We are seeking an enthusiastic and highly motivated candidate, with a MSc degree in a relevant discipline (Biology, Biomedical or Molecular Sciences, Immunology, or (Veterinary) Medicine). Some experience with various molecular, immunological and/or and virological techniques is necessary. Experience with in vivo studies (art. 9 certified) is an asset.
If you are interested in this position, please send your resume and application letter to: Dr. C.H. Geurts van Kessel (project leader), e-mail:
Additional information on the project can be acquired through the same email address or
by phone (Dr. C.H. Geurts van Kessel): number: (+31)(0)10 704 4066