Sub theme 2.5
Immune regulation and autoimmunity


Goals of research: general outline
Scientific achievements
Future plans: special goals and approach
Running projects
Associated staff

Workgroup leaders   Department
prof.dr  P.A.  van  Doorn   Neurology
Prof.dr.  H.A.  Drexhage   Immunology
dr.  R.Q.  Hintzen   Neurology
dr  B.C.  Jacobs   Neurology
Dr.  P.J.M.  Leenen   Immunology
Dr.  V.H.J.  van der  Velden   Immunology

Goals of research: general outline

The Dept. of Immunology focuses on lymphatic and myeloid differentiation, immune regulation and inflammation. Chronic inflammation and autoimmune disease are leading causes of morbidity, psycho-siocal burden and economic loss in Western societies. In view of the central role of innate and adaptive immunity in these diseases, detailed insight into immune regulation is a requirement for elucidation of the immune pathogenesis of chronic inflammatory and autoimmune processes and the rational development of diagnostics and immune therapy.

The Postgraduate School Molecular Medicine has an extensive and active program in immune regulation and autoimmunity, consisting of a close collaboration between clinical and pre-clinical departments. Chronic inflammatory diseases of interest are type I diabetes, thyroiditis, affective disorders and schizophrenia (all having a major immuno-neuro-endocrine component), rheumatoid arthritis (RA) and the related disorder Sjögren’s disease, psoriasis, and the demyelinating diseases multiple sclerosis (MS) and Guillain-Barré syndrome (GBS).

 

The general premise is that the immune mechanisms driving the multi-factorial pathological processes in these different diseases of interest are highly analogous. Our overall aims within the frame of aforementioned diseases are to unravel:

  • The immune (dys-)regulations in inflammatory capacity and antigen-presentation and the set point changes in monocytes, dendritic cells and macrophages underlying these diseases
  • The numerical and functional abnormalities in T and B lymphocyte subsets underlying these diseases
  • The influences of the neuro-endocrine system on leukocyte-target organ interaction
  • The microbial and neuro-endocrine compounds driving the immune dys-regulations and the chronic inflammations
  • The molecular mimicry and cross-reactivity for auto-antibody neurotoxicity
  • The development of innovative animal models including conditional and cell type-specific transgenesis.

Research topics include basic immune pathogenic mechanisms (e.g. molecular mimicry in GBS and MS); immune-endocrine interactions (e.g. in the pathogenesis of postpartum thyroiditis and psychosis and in the linked amelioration of MS, thyroiditis and RA during pregnancy); molecular signaling pathways in chronic autoimmune inflammation (e.g. transcription factors in psoriasis and major psychiatric diseases, inflammatory gene signature expression in monocytes in major psychiatric and autoimmune diseases, epi-genetic regulation of these various genes); experimental immune therapy (e.g. antibodies against co-stimulatory molecules and cytokines); immune regulation by external factors (e.g. UV irradiation and skin inflammation, infection and MS activity); immune function and disease activity in MS; and immune dysregulation by aberrant development and activity of antigen presenting cells (e.g. in diabetes, Sjögren’s syndrome, thyroiditis, atherosclerosis, affective disorders, schizophrenia and histiocytosis).

Team

Close collaboration with clinical researchers who are well trained in immunology allows joint elaboration of scientifically relevant research questions, construction of well-characterized patient cohorts, and evaluation of experimental immune therapies. Specifically, the departments of Neurology (workgroup leaders Prof.Dr. R.Q. Hintzen, Dr. B.C. Jacobs, Prof.Dr. P.A. van Doorn), Dermatology (Prof.Dr. H.A.M. Neuman, Prof.Dr. E.P. Prens), Rheumatology (Prof.Dr. J.M.W. Hazes, Dr. E. Lubberts, Dr. R.J.E.M. Dolhain) and Internal Medicine (Dr. P.M. van Hagen) have integrated their immune research within this research line of the Molmed School.

There is additional close collaboration on the role of microbial compounds in immune regulation with the departments of Virology (Prof.Dr. A.D.M.E. Osterhaus), Medical Microbiology and Infectious Diseases (Prof.Dr. H.A. Verbrugh, Dr. H.P. Endtz, Prof.Dr. A. van Belkum). Furthermore, the departments of Internal Medicine (Prof.Dr. A.J. van der Lely, Prof.Dr. T.J. Visser) and Immunology collaborate on thyroid autoimmune disease and on diabetes, and the departments of Psychiatry (Prof.Dr. S. Kushner, Dr. V. Bergink, Dr. J.M. van Beveren) and Immunology on immune aberrancies in major affective disorders and schizophrenia. In addition, long-standing collaborations exist with the department of Genetics (Prof.Dr. J.H.J. Hoeymakers, Dr. J. Pothof) on UV-mediated effects on immunity and microRNA regulation of gene expression. Combining researchers with different backgrounds (e.g. the clinic, molecular biology, cellular immunology) working on these different diseases in a single integrated team significantly stimulates scientific discussion and output. The joint expertise allows coverage of a broad area of approaches and technology, ranging from patient cohort studies via functional in vitro and genetic analyses of patient material to several animal disease models in rodents and non-human primates including the generation of novel (conditional) transgene and knockout mouse models.


Scientific achievements
  1. Distinct profiles of microRNAs were identified in different developmental stages of dendritic cells. Differentially expressed microRNAs were found to regulate M-CSF receptor expression, which appeared to be decisive in final maturation of these pivotal immune-regulating cells.
  2. In addition to dendritic cell plasticity and multi-tasking the concept of division of labor between distinct dendritic cell subsets, e.g. in governing immunity versus tolerance, is gaining support. To unravel the relative importance of epidermal Langerhans cells versus dermal dendritic cells in the control of skin immunity and tolerance, we have developed a transgenic Langerhans cell depletion mouse model. Furthermore, we are applying dendritic cell-specific Cre/loxP-mediated gene targeting to better understand the molecular signals directing dendritic cell function
  3. We idebtified abnormal local precursors for dendritic cells in the pancreas in a mouse model for type I diabetes.
  4. Coherent partly overlapping, but distinct inflammatory transcriptomic fingerprints were detected in the monocytes of proportions of patients with bipolar disorder, schizophrenia, LADA, childhood onset type 1 diabetes, autoimmune thryroid disease and Sjögren’s disease reflecting previously found functional abnormalities in these cells; these fingerprints will be instrumental for the development of novel diagnostic and prognostic biomarker assays and for the identification of patients benefiting from a treatment targeting important fingerprint genes (COX-2, PDE4B, TNF, IFN-α)
  5. We developed in vitro assays in which the role of ganglioside-like lipo-oligosaccharides of Campylobacter jejuni in the activation of human dendritic cells and B-cells was established.
  6. We developed accurate and validated prognostic models based on early clinical and immunological characteristics to predict the IVIg treatment response and outcome in individual patients with the Guillain-Barré syndrome.  
  7. B-cell clonality in cerebrospinal fluid of MS patients as an early event in the disease course was established.
  8. The influence of pregnancy on T-lymphocyte function in MS and healthy individuals was established.
  9. We found effects of novel MS and autoimmune risk genes on T-cell responses.
  10. Using innovative EAE models and MS patient material in parallel, we demonstrated that phagocytic cells turned foam cell by excessive myelin uptake having anti-inflammatory function, that bacterial peptidoglycan is a cofactor in brain inflammation, and that lymph nodes draining myelin and axonal antigen from the brain contribute to disease relapse.

Future plans: special goals and approach
  1. The further development within MOODINFLAME of monocyte, T cell and serum biomarker assays to diagnose and to identify individuals at risk to develop bipolar disorder, major mood disorders, post partum psychosis, schizophrenia, type 1 diabetes, autoimmune thyroid disease and Sjögren’s disease and the treatment of these patients/at risk individuals with new generation COX-2 inhibitors, PDE4B inhibitors, anti-oxidants, anti-TNF and anti IFN-receptor biologicals (personalized treatments)
  2. Substantiate the mediators and pathways involved in the cross-reactive immune response to preceding infections that result in the Guillain-Barré syndrome.
  3. Coordinate extensive international studies on disease modifiers and prediction of the treatment response and outcome in the Guillain-Barré syndrome, in collaboration with the International Neuropathy Consortium (INC) and Peripheral Nerve Society (PNS).
  4. We will continue to apply conditional in vivo mutagenesis to better understand the role and molecular control of dendritic cells and monocytes/macrophages in immune regulation. Furthermore, we have recently made Langerhans cells accessible to this powerful approach by generating Langerhans cell-specific Cre mice. Functional analysis of these tg/KO mice will focus on relevant disease models of psoriasis (in cooperation with Prof.Dr. E.P. Prens, Dept. Dermatology), multiple sclerosis, rheumatoid arthritis (in cooperation with Dr. E. Lubberts, Dept. Rheumatology), allergic asthma (Prof.Dr. B.N.M. Lambrecht, Dr. R.W. Hendriks, Dept. Pulmonology) and colitis/IBD models (Dr. J.N. Samsom, Dept. Paedriatrics).
  5. Animal EAE models will be further improved in both rodents and non-human primates to more faithfully mimick components of MS pathogenesis by applying conditional mutagenesis and alternative adjuvant strategies. Contributions of infectious pathogens as well as normal gut flora to MS/EAE susceptibility and disease course will be assessed. Tolerance control by glycosylation of brain components will be investigated.
  6. To apply microRNA technology as an investigative, diagnostic and therapeutic tool to monitor and manipulate the developmental and activation state of myelomonocytic cells involved in various inflammatory conditions in patients and animal models of human disease. These include diabetes, psychiatric disease, histiocytosis, bacterial infection and atherosclerosis.

Most recent publications

1.      Padmos RC, Schloot NC, Beyan H, Ruwhof C, Staal FJ, de Ridder D, Aanstoot HJ, Lam-Tse WK, de Wit H, de Herder C, Drexhage RC, Menart B, Leslie RD, Drexhage HA; LADA Consortium. Distinct monocyte gene-expression profiles in autoimmune diabetes. Diabetes 2008; 57:2768-73.

2.      Padmos RC, Hillegers MH, Knijff EM, Vonk R, Bouvy A, Staal FJ, de Ridder D, Kupka RW, Nolen WA, Drexhage HA. A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry. 2008; 65:395-407.

3.      van Koningsveld R, Steyerberg EW, Hughes RAC, Swan AV, van Doorn PA, Jacobs BC. A clinical prognostic scoring system for Guillain-Barré syndrome. Lancet Neurol 2007;6:589-94.

4.      van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis and treatment of Guillain-Barré syndrome. Lancet Neurol 2008;7:939-50.

5.      Bennett CL and Clausen BE. Dendritic cell ablation in mice: promises, pitfalls and challenges. Trends Immunol. 2007; 28:519-25.

6.      Bennett CL, Noordegraaf M, Martina CA, Clausen BE. Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J Immunol. 2007; 179:6830-5.

7.      Boven LA, van Meurs M, van Zwam M, Wierenga-Wolf A, Hintzen RQ, Boot RG, Aerts JM, Amor S, Nieuwenhuis EE, Laman JD. Myelin-laden macrophages are anti-inflammatory consistent with foam cells in multiple sclerosis. Brain 2006; 129:517-26.

8.      ‘t Hart BA, Hintzen RQ, Laman JD. Multiple sclerosis, a response-to-damage model. Trends Mol Med. 2009; 15:235-44.

9.      Hintzen RQ, Giovannoni G. CSF analysis in suspected MS: do bands aid? Neurology 2008; 70:1059-60.

10.  Neuteboom RF, Boon M, Catsman Berrevoets CE, Vles JS, Gooskens RH, Stroink H, Vermeulen RJ, Rotteveel JJ, Ketelslegers IA, Peeters E, Poll-The BT, De Rijk-Van Andel JF, Verrips A, Hintzen RQ. Prognostic factors after a first attack of inflammatory CNS demyelination in children. Neurology 2008; 71:967-73.

11.  de Lau LM, de Vries JM, Kuipers E, van der Woude CJ, Kuipers EJ, Siepman DA, Sillevis Smitt PA, Hintzen RQ. Acute CNS white matter lesions in patients with inflammatory bowel disease. Inflammatory Bowel Diseases 2009; 15:576-80.

12.  Sunderkotter C, Nikolic T, Dillon MJ, Van Rooijen N, Stehling M, Drevets DA, Leenen PJM. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol. 2004; 172:4410-7.

13.  Cheng C, Tempel D, van Haperen R, de Boer HC, Segers D, Huisman M, van Zonneveld AJ, Leenen PJM, van der Steen A, Serruys PW, de Crom R, Krams R. Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines. J Clin Invest. 2007; 117:616-26.

14.  Wildenberg ME, van Helden-Meeuwsen CG, van de Merwe JP, Drexhage HA, Versnel MA. Systemic increase in type I interferon activity in Sjögren's syndrome: a putative role for plasmacytoid dendritic cells. Eur J Immunol. 2008;38:2024-2033.


People associated with sub theme 2.5: Immune regulation and autoimmunity
Name Position Department
M  van den   Aakster MSc student (please specify in remarks) Viroscience
Z.  Alvandi PhD-candidate Virology
H.  Alves Postdoc/junior researcher Rheumatology
CC  Amoo PhD-candidate Gastro-enterology and Hepatology
dr.  C.W.  Ang Senior researcher not being a workgroup leader Medical Microbiology & Infectious Disease
J.  Anink PhD-candidate Pediatrics
Thun  AnitaKeect Postdoc/junior researcher General Surgery
drs.  C.B.  Ardon PhD-candidate Dermatology
J.A.  Arnold MSc student (please specify in remarks) Immunology
Ladyofrage  ArtemMace Senior researcher not being a workgroup leader General Surgery
Сп&  Smooveb73  athleticKema Workgroup leader within the School General Surgery
Drs.  E.M.  Baerveldt PhD-candidate Dermatology
MD, MSc  D.M.W.  Balak PhD-candidate Dermatology
L.B.  Baldeon PhD-candidate Immunology
BSc  J.  Bastiaans PhD-candidate Immunology
A.F.  Bekebrede MSc student (please specify in remarks) Infectious Diseases
Ing.  I.M.  Bergen Technician Pulmonary Diseases
W.  Beumer Other as mentioned (please specify in remarks) Immunology
M.L.  Bexkens PhD-candidate Medical Microbiology & Infectious Disease
C.E.F.  van  Bilsen PhD-candidate Internal Medicine
MSc  N.K.  Bister PhD-candidate Urology
Dr.  S.  van  Blokland PhD-candidate Immunology
MSC  I.L.A.  Bodewes PhD-candidate Immunology
N.P.  Boeddha PhD-candidate Pediatrics
MD  GM  de  Boer PhD-candidate Pulmonary Diseases
A.  Bondt PhD-candidate Rheumatology
Drs.  P.A.  Boonstra
drs  G.  Bouma PhD-candidate Immunology
A.T.  Bourne MSc student (please specify in remarks) Postgraduate School
dr  L.A.  Boven Senior researcher not being a workgroup leader Immunology
MSc  M D  Brem PhD-candidate Immunology
Drs.  Z.  Brkic PhD-candidate Bio Chemistry
MD, PhD candidate  A.L.  Bruijstens PhD-candidate Neurology
Msc  A.M.  de  Bruin PhD-candidate Immunology
A.P.C.A.  Carranco Arenas MSc student (please specify in remarks) Student
D.  Caudri PhD-candidate Pediatrics Lung Diseases
MD  W.K.  Chan PhD-candidate Immunology
Prof.dr  E.  Claassen Senior researcher not being a workgroup leader Virology
Dr.  B.E.  Clausen Workgroup leader within the School Immunology
MSc  MCP  Cleophas PhD-candidate Experimental Internal Medicine
S.C.  Clockaerts PhD-candidate Orthopaedics
Prof  P.J.C.  Coffer Professor not being a workgroup leader Immunology
L.M.M.  Costes Postdoc/junior researcher Pediatrics
T.O.  Crisan PhD-candidate Medicine
MSc  W.  Dankers PhD-candidate Rheumatology
Drs.  T.D.  Das PhD-candidate Lung Diseases
A.M.J.D.  de Bruin-Vanlaerhoven PhD-candidate Dermatology
C.C.  van  Diemen Postdoc/junior researcher Medical Genetics
dr  W.A.  Dik Senior researcher not being a workgroup leader Immunology
dr  R.J.E.M.  Dolhain Senior researcher not being a workgroup leader Rheumatology
prof.dr  P.A.  van  Doorn Workgroup leader within the School Neurology
Prof.dr.  H.A.  Drexhage Workgroup leader within the School Immunology
PhD  M.M.  van  Duijn Postdoc/junior researcher Neurology
dr.  L.  van der  Fits Senior researcher not being a workgroup leader Immunology
Drs.  W.J.R.  Fokkink PhD-candidate Immunology
Dr.  B.  Franke Assistent professor (UD) Genetics
Dr.  G.M.  Fuhler Senior researcher not being a workgroup leader Gastro-enterology and Hepatology
drs  F.E.  van de   Geijn PhD-candidate Rheumatology
dr  C.P.W.  Geleijns PhD-candidate Immunology
Dr.  R.  van  Gent Postdoc/junior researcher Gastro-enterology and Hepatology
MD  C.H.  Geurts van Kessel PhD-candidate Pulmonary Diseases
drs  S.  Geutskens PhD-candidate
M.J.H.  Girard-Madoux PhD-candidate Immunology
drs.  A.K.  Gloudemans PhD-candidate Pulmonary Diseases
Drs  DM  Goilo PhD-candidate Viroscience
JF  de  Graaf PhD-candidate Virology
D.D.  Grancharova PhD-candidate CODT
M.S.  Gresnigt PhD-candidate Experimental Internal Medicine
RA  Groen Technician Immunology
C.G.  Grosserichter-Wagener PhD-candidate Immunology
A.B.  de  Haan Other as mentioned (please specify in remarks) Pulmonary Diseases
PhD  C.  de  Haar Postdoc/junior researcher Gastro-enterology and Hepatology
Dr.  A.H.  Haghighi Physician (MD) Medical Genetics
MD, PhD  A.E.  Hak Physician (MD) Immunology
Dr.  H.J.  van den  Ham Postdoc/junior researcher Virology
prof.dr  J.M.W.  Hazes Senior researcher not being a workgroup leader Rheumatology
MSc  W.A.  van der   Heijden PhD-candidate Internal Medicine
Social pictures  Paulpeter  henrysl4 Professor not being a workgroup leader General Surgery
M.H.  den  Hertog Technician Neurology
M.H.  den  Hertog Technician Neurology
P.H.  Heukels PhD-candidate Pulmonary Diseases
D.  van den   Heuvel MSc student (please specify in remarks) Immunology
dr.  R.Q.  Hintzen Workgroup leader within the School Neurology
drs  I.A.  Hoppenbrouwers PhD-candidate Neurology
MSc  E  Huijser PhD-candidate Immunology
Dr.  H.G.  Huizinga Postdoc/junior researcher Immunology
JAC  van  Hulst Technician Pulmonary Diseases
H.  IJspeert Other as mentioned (please specify in remarks) Hematology
QettoE  IsrafacemoM Workgroup leader within the School General Surgery
dr  B.C.  Jacobs Workgroup leader within the School Neurology
Msc  H.H.M.  Jaeger PhD-candidate Experimental Internal Medicine
Drs.  N.  Jafari PhD-candidate Neurology
S.A  Jagessar PhD-candidate Immunobiology
Tmmaverick  JamesFlupe Physician (MD) General Surgery
P.M.  Jansen PhD-candidate Internal Medicine
MSc  M  Janssen PhD-candidate Neurology
Dr.ir.  H.J.I.  de  Jong Postdoc/junior researcher Immunology
M.M.E.  de  Jong MSc student (please specify in remarks) Student
G.M.  de  Jong MSc student (please specify in remarks) Student
M.J.  Kallemeijn MSc student (please specify in remarks) Postgraduate School
MSc  Y.S.  Kap PhD-candidate Immunology
J.J.  Karrich Postdoc/junior researcher Hematology
Dr.  J.M.  Kel Postdoc/junior researcher Immunology
Drs.  P.M.J.H.  Kemperman PhD-candidate Dermatology
M.M.  Khalid MSc student (please specify in remarks) Bio Chemistry
drs  N.A.  Khan PhD-candidate Immunology
MSc  L.P.  Kil PhD-candidate Pulmonary Diseases
T  Klein Senior researcher not being a workgroup leader Clinical Chemistry
R.G.J.  Klein Wolterink Postdoc/junior researcher Pulmonary Diseases
dr.  E.M.  Knijff PhD-candidate Immunology
MSc  V.A.C.M.  Koeken PhD-candidate Internal Medicine
MSc  S.C.  Koetzier PhD-candidate Immunology
M. K.  Konings Technician Medical Microbiology & Infectious Disease
ing  M.  Kool PhD-candidate Lung Diseases
Drs.  D.C.  Koopal MSc student (please specify in remarks) Immunology
MD  P.K.  P.  Koumoutsakos PhD-candidate Internal Medicine
G.  Kozdras MSc student (please specify in remarks) Student
MSc  A.E.  Kozijn PhD-candidate Gastro-enterology and Hepatology
L.A.P.  Krassenburg MSc student (please specify in remarks) Student
Drs., MSc  K.L.  Kreft PhD-candidate Neurology
B.K.  Kruisinga MSc student (please specify in remarks) Infectious Diseases
R.  La Distia Nora PhD-candidate Immunology
drs  M.P.  Laan
Prof.dr.  J.D.  Laman Senior researcher not being a workgroup leader Neurology
drs  W.K.  Lam-Tse PhD-candidate Internal Medicine
drs  M.S.  Lang
Dr.  P.J.M.  Leenen Workgroup leader within the School Immunology
Drs.  C.  Liem PhD-candidate Virology
M.M.  van  Luijn Postdoc/junior researcher Immunology
Drs.  C.B.M.  Maassen
M.D.  O.R.  Manusama PhD-candidate Immunology
Msc  N.M  Maria PhD-candidate Immunology
C.L.  Menckeberg Postdoc/junior researcher Pediatrics
F.K.F.  Mensah MSc student (please specify in remarks) Postgraduate School
Dr  P.M.M.S.  Meyer Sauteur PhD-candidate Pediatrics
drs.  M.M.F.  van  Mierlo PhD-candidate Dermatology
drs.  M.M.F.  van  Mierlo PhD-candidate Dermatology
M.T.M.  Mitul MSc student (please specify in remarks) Immunology
M.  Molendijk PhD-candidate Rheumatology
K.F.  Morales PhD-candidate Virology
Smooveb73  NancyBlown Physician (MD) General Surgery
E.G.  Neelis PhD-candidate Pediatrics
prof.dr  H.A.M.  Neumann Senior researcher not being a workgroup leader Dermatology
R.F.  Neuteboom PhD-candidate Neurology
S.F.H.  Neys MSc student (please specify in remarks) Immunology
BSc  G.P.  van  Nierop PhD-candidate Virology
EC  Noels PhD-candidate Dermatology
S.  Nugteren MSc student (please specify in remarks)
S  Nugteren PhD-candidate Pediatrics
Dr.  J.O.  Ober-Blobaum Postdoc/junior researcher Immunology
BSc  M.D.O.  Oduber MSc student (please specify in remarks) Postgraduate School
S.  Oktaria PhD-candidate Dermatology
MSc student I&I  D.O  Ozkazanc MSc student (please specify in remarks) Immunology
N.P.  Papazian Technician Hematology
MSc  S.M.J.  Paulissen PhD-candidate Rheumatology
Ing.  A.M.A.  Peeters Technician Internal Medicine
Drs.  E.D.  van  Pelt PhD-candidate Neurology
MSc  M.J.   Poen PhD-candidate Virology
dr  E.P.  Prens Senior researcher not being a workgroup leader Immunology
Ing  L.B.V.  Provacia Technician Virology
Dr.  E.R.  Racz PhD-candidate Dermatology
Drs.  W  Razawy PhD-candidate Rheumatology
MSc.  G.A.  Reumer PhD-candidate Molecular Oncology
Drs.  J.  Riepsaame PhD-candidate Immunology
MSc  L.C.  Rijsbergen PhD-candidate Virology
MSc  L.  Rijvers PhD-candidate Immunology
J  Rip PhD-candidate Pulmonary Diseases
M.  Romrea Hernandez PhD-candidate Hematology
drs  S.H.M.  Rooijakkers PhD-candidate Medical Microbiology & Infectious Disease
drs.  J.A.  Ropela PhD-candidate Hematology
L.F.  de  Ruiter Technician Pediatrics
dr  C.  Ruwhof Senior researcher not being a workgroup leader
B.  Schrijver Technician Immunology
T.A.  Siepman Postdoc/junior researcher Neurology
Drs  Vaibhav  Singh PhD-candidate Neurology
Drs.  V.  Singh PhD-candidate Neuro Oncology
G.J.  Sips Physician (MD) Medical Microbiology & Infectious Disease
JAM  Sleutjes PhD-candidate Gastro-enterology and Hepatology
PhD  S.L.  Smits Postdoc/junior researcher Virology
dr  A.  Snijders Senior researcher not being a workgroup leader
Mr  R.  Somasundaram PhD-candidate Gastro-enterology and Hepatology
drs  V.  Sommandas PhD-candidate Immunology
dr  P.  Spantidea Postdoc/junior researcher Immunology
Drs.  L.  van  Steensel Physician (MD) Surgery
drs  M.P.  Stoop PhD-candidate Neurology
K.R.  van  Straalen PhD-candidate Anaesthesiology
drs.  K.R.  van  Straalen PhD-candidate Dermatology
Drs.  M.W.J.  Swinkels PhD-candidate Hematology
MSc  A.  al  Tarique Technician Virology
M.  Tempelsmans Plat Technician Immunology
K  Thiem Assistent professor (UD) Internal Medicine
dr.  H.B.  Thio Senior researcher not being a workgroup leader Dermatology
Drs.  S.P.R.  Tillemans PhD-candidate Rheumatology
I  Tindemans Postdoc/junior researcher Pediatrics
dr.  E.J.M.  Toonen Postdoc/junior researcher Immunology
N.V.  Valeri MSc student (please specify in remarks) Pulmonary Diseases
N.V.  Valeri MSc student (please specify in remarks) Pulmonary Diseases
MD  G  van den Brink PhD-candidate Pediatrics
J  van Langelaar PhD-candidate Immunology
Drs.  C.  Veen Other as mentioned (please specify in remarks) Psychiatry
S.  Veenbergen Postdoc/junior researcher Pediatrics
Dr.  V.H.J.  van der  Velden Workgroup leader within the School Immunology
Drs, MSc  J.  Versmissen PhD-candidate Internal Medicine
dr  M.A.  Versnel Senior researcher not being a workgroup leader Immunology
B.E.  Verstrepen PhD-candidate Gastro-enterology and Hepatology
Dr.  L.  Visser Postdoc/junior researcher
MD  E.A.M.  van der  Voort PhD-candidate Dermatology
A.R.J.V.  Vossen PhD-candidate Dermatology
Drs.  R.M.  van der  Vuurst de Vries PhD-candidate Neurology
K.W.  Weigelt PhD-candidate Immunology
Ing., PhD  J.M.C.  Welzen-Coppens PhD-candidate Immunology
M.  Wildenberg PhD-candidate Immunology
Dipl. Biol.  C.W.  Wohn PhD-candidate Immunology
prof.dr  B.W.  Wollenberg Senior researcher not being a workgroup leader Immunology
MD  Y.Y.M.   Wong PhD-candidate Neurology
X  XU PhD-candidate Rheumatology
Dr.  G.  Yanbaeva Postdoc/junior researcher Pulmonary Diseases
M.Z.  van der   Zee PhD-candidate Obstetrics and Gynaecology
M.Z  Zhao PhD-candidate Gastro-enterology and Hepatology